HIV transmission and sexually transmitted infections.
نویسنده
چکیده
Clinical Medicine Vol 8 No 3 June 2008 323 © Royal College of Physicians, 2008. All rights reserved. HIV is a sexually transmitted infection (STI) which causes AIDS and death in most of those infected after a median of 8–10 years. Where antiretroviral therapy is available, HIV is now regarded as a manageable chronic condition. Prevention remains a high priority and the potential to reduce the number of those acquiring HIV through better control of STIs remains tantalising. This article will review the evidence that STIs are important cofactors for HIV transmission and acquisition. HIV itself is sexually transmitted so it is often difficult to exclude confounding from observational studies.1 The time sequence of infections cannot be ascertained easily in cross-sectional studies so longitudinal studies are required. Studies of the effect of STIs on genital tract shedding of HIV provide biological plausibility for mechanisms to associate increased transmission from those with STIs. Randomised controlled studies (RCTs) of the impact on HIV seroconversion rates of interventions to control other STIs are the best measure of their importance. Observational studies
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ورودعنوان ژورنال:
- Clinical medicine
دوره 8 3 شماره
صفحات -
تاریخ انتشار 2008